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This early work established the principle that GHK-Cu acts as a signalling molecule rather than simply a structural component, setting the stage for decades of investigation across multiple research domains
Expression of metE is repressed by a cobalamin riboswitch, while MetH requires the cobalamin cofactor
GSH availability is studied across aging, exercise, environmental exposure, liver biology, neurobiology and tissue-recovery models involving oxidative stress
Future research applications will likely expand to include investigation of senescence heterogeneity, tissue-specific senescent cell populations, and the development of personalized approaches to senolytic intervention based on individual senescent cell burden and characteristics
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