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As observed in H&E staining, FA injection induced severe tubular damage, indicated by detachment of tubular cells, dilation of tubules, swelling of tubular cells, degeneration of epithelial cells, and interstitial inflammatory cells infiltration
Notably, the deletion of lipogenic enzymes in the liver, such as acetyl-CoA carboxylase 1/2 (ACC1/2), has been reported to liberate NADPH for antioxidant processes, including GSH regeneration 87
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even a small droplet may be lethal
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