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There are multiple FDA-approved and affordable prescription options available, including alternatives for those no longer able to access compounded semaglutide or tirzepatide
Tirzepatide induces substantial weight losstypically 5-10% in type 2 diabetes and 15-20% in obesity without diabetes at therapeutic doseswhich can directly reduce cardiac workload and peripheral vascular resistance
Adipose tissue, particularly when present in excess, acts as an endocrine organ, secreting hormones that can disrupt the delicate hormonal balance necessary for ovulation and fertility
Moreover, the common side-effect of GLP1R agonists in producing nausea is attributed to GLP1R-expressing neurons in the Area Postrema [20] , which is well known to regulate processes such as vomiting in humans
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