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Furthermore, a new orally bioavailable GLP-1RA, oral hypoglycemic peptide 2 (OHP2), can confer protective effects on diabetic cardiomyopathy through rescuing cardiac lipotoxicity by inhibiting Rho (the small GTPase) kinase (ROCK)/PPAR pathway [89, 90] (Figure 1)
In healthy muscle and endothelium, the postprandial ROS burst is normally self-limited by nuclear factor erythroid 2related factor 2 (Nrf2)driven induction of glutathione peroxidase, catalase, and heme oxygenase-1 (8891)
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