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Lifestyle modification remains the fundamental basis of MASLD treatment, and pharmacological treatment is increasingly recognized as fundamental support, mainly in patients with biopsy-confirmed MASH, significant fibrosis ( F2), or cardiometabolic comorbidity 8
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Pemvidutide Pemvidutide, another weekly GLP-1/glucagon dual agonist, is under evaluation in the ongoing phase 2 IMPACT trial (NCT05989711) in 190 individuals with histologically confirmed MASH and fibrosis stages F2-F3 [47]
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