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Documentation and Prescription Requirements Carry your original prescription label on the semaglutide pen or vial, along with a letter from your healthcare provider confirming the medication is medically necessary for your weight management treatment
Optometrists should perform a baseline dilated comprehensive eye examination on patients who take these medications for any reason to determine their pre-existing level of DR and whether they have any risk factors for developing NAION
Key points: In the only head-to-head trial, Wegovy produced 15.8% weight loss compared with 6.4% for Saxenda over the same 68-week period Wegovy 7.2 mg (approved January 2026) produces even greater results at 20.7% average weight loss Real-world data from Second Nature shows 19.1% weight loss with semaglutide when combined with behavioural support Semaglutide participants were nearly three times more likely to achieve at least 10% weight loss than liraglutide participants Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract
GLP-1 only treatments and oral options still deliver strong results but typically show slightly lower average weight loss because they target a single receptor pathway
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