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Cell (2017) This landmark Cell publication from Erasmus University Medical Center introduced FOXO4-DRI as a senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4-p53 interaction

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KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats

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Theoretical concerns include off-target cell death, immune burden from clearing many cells at once, impaired wound healing, and injection-site irritation

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