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In the trial, 104 subjects with high blood pressure and high homocysteine levels (15 mol/L) received either 5,000 mcg of folic acid per day or a daily supplement providing 400 mcg of folate (as 5-MTHF), 5 mcg of B 12 , 3 mg of B 6 , and 2.4 mg of B 2 , as well as 12.5 mg of zinc and 250 mg of betaine

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