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In this pathway, cGAS dimerizes upon binding to cytoplasmic double-stranded DNA and is catalyzed to synthesize 2,3- cyclic GMP-AMP (cGAMP), which acts as a second messenger to bind and activate STING (93)
The tar phase of cigarette smoke contains long-lived radicals, while the gas phase contains short-lived radicals such as nitric oxide and superoxide
It does not just work in one area
(13) The peptide may act indirectly by steadying the vascular setting required for new vessel growth
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