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The Today Show reported in 2025 that dermatologists see very little lasting effect from topical firming creams

Therefore, regulatory authorities required additional pharmacovigilance activities, by systematically monitoring the annual incidence of MTC in the US for at least 15 years (MTC-22341, results expected by 20352037)

Your GP may need to reduce your dose accordingly

Until that point, its use outside of approved clinical trials is not sanctioned by UK regulatory authorities, and the risks of self-administration particularly involving home reconstitution of an unregulated product far outweigh any potential benefit