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Stephanie Wolff is a Physician Assistant and Hormone and Peptide Expert from the Novus Anti-Aging Center in California

Presented for research literature review only Irwin C et al

In the next, extremely unfavorable elimination step (step 2), the conjugate base of the amine is kicked out from the tetrahedral intermediate: The reaction is driven to completion in a quick, irreversible deprotonation of the carboxylic acid by the newly formed RNH

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