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Sarcopenia aetiology is multi-factorial, driven by progressive anabolic resistance to nutrition and physical activity [36, 37], and age-related structural (vertebral compression and unfavourable fat deposition [38]), metabolic (reduced basal metabolic rate [39]) and hormonal (lower circulating anabolic hormones (testosterone, growth hormone and insulin-like growth factor-1)) changes

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This dual action produces multiple metabolic effects: Appetite suppression through central nervous system pathways affecting satiety centers Delayed gastric emptying , which prolongs feelings of fullness Enhanced insulin secretion in a glucose-dependent manner Reduced glucagon secretion , decreasing hepatic glucose production Weight loss-associated improvements in insulin sensitivity in peripheral tissues These effects occur systemically after subcutaneous absorption, with median peak concentrations reached in approximately 48-72 hours and a half-life of about 5 days allowing once-weekly dosing

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