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Only 57% of REDEFINE 1 participants reached the 2.4/2.4 mg maintenance dose, which suggests many people wont be able to tolerate the higher doses of the drug

In addition, a recent study revealed that food restriction increases plasma ClpB levels, which is associated with the increased relative abundance of Enterobacteriaceae and intestinal permeability, and in turn increases satiety by activating anorexigenic neurons in mice [96]

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Comparison Snapshot: Tirzepatide versus Semaglutide Clinical trials show both medications are effective for weight reduction, but tirzepatides dual GIP and GLP-1 activity produced larger average weight loss than semaglutide in head-to-head studies