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Patients with pre-existing severe motility issues may experience worse symptoms
DSIP + Ipamorelin Stack Protocol Dose: 200 mcg DSIP + 200 mcg Ipamorelin Timing: Both injected 30 minutes before bed Cycle: 4 to 8 weeks on, 2 to 4 weeks off Best for: Athletes, recovery-focused users, anti-aging protocols This is the sleep-and-recovery stack
Lower opioid dose if returning to use
The Sikiric group's own review body additionally proposes a broader "brain-gut axis" of cytoprotective signaling, explicitly framed by the authors as theoretical, not an established mechanism (Sikiric et al
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