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The REDEFINE 4 trial: the definitive showdown Everything discussed above relies on cross-trial comparisons, which carry inherent limitations

Presented for research literature review only Ketterer B et al

Trial REDEFINE 2 Phase 3 Duration 68 weeks Population (N) 1,206 adults with T2D + obesity/overweight Key Result 13.7% mean weight change vs 3.4% placebo (treatment-policy)

As described in a new paper published in Science , Kvan Birsoy and his colleagues in Rockefellers Laboratory of Metabolic Regulation and Genetics have discovered the first such sensor for an organellespecifically mitochondria, the cells power center