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The deficiency of DHEA in inflammatory diseases also implies a deficiency in peripheral tissue of various sex hormones for which DHEA serves as a precursor
It signals the brain to reduce appetite, stimulates insulin secretion from the pancreas, suppresses glucagon, and slows gastric emptying
Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time
Without structure, most patients backslide
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