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In the 6-OHDA-induced PD model, iron promotes LRRK2 activation via phosphorylation at S935 and S1292 sites
Interestingly, DPP-4 inhibition does not have to take place systemically but only in the intestine as shown with oral administration of low doses of inhibitor (122)
TML undergoes a series of enzymatic reactions, including -N-trimethyl-lysine hydroxylase (HTMLA), -butyryl transferase (BBOX), etc., and is finally converted into L-carnitine
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