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In June 2025, the World Health Organization (WHO) warned that semaglutide drugs, such as Ozempic, Wegovy and Rybelsus, may rarely cause NAION

For further scientific context, you can review peptide research via the National Center for Biotechnology Information (NCBI) peptide research database and broader metabolic pathway insights from the World Health Organization (WHO)

Faerch K, Torekov SS, Vistisen D et al (2015) GLP-1 response to oral glucose is reduced in prediabetes, screen-detected type 2 diabetes, and obesity and influenced by sex: the ADDITION-PRO study

Annual measurement of B12 levels in those on longterm meformin therapy has been recommended since the 1970's