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GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]
(in biology) A term referring to movement
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And it doesnt cause weight gain, is highly effective when taken consistently, doesnt cause hypoglycemia, and its relatively affordable. While the impact of metformin is significantly more subtle and gradual than that of GLP-1s, its still beneficial for almost anyone with diabetes, regardless of other medications
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