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You need to synthesize a vast and murky scientific landscape

So the issue is not that nobody studies it because it is cheap. The issue is that the evidence we have supports modest metabolic effects, not drug-level obesity treatment effects

Additionally, studies have indicated that GLP-1RAs may directly stimulate acinar cells, leading to increased pancreatic enzyme levels and a potential pathway for the development of pancreatitis 14,15

Several observational studies have found associations between opioid use and increased health care utilization among patients with cirrhosis [12, 26, 27], and worse outcomes among the subset that undergo liver transplant [28]