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Farzaei MH, Abdollahi M, Rahimi R

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MOTS-c functions as a powerful metabolic regulator by activating AMPK (AMP-activated protein kinase), a master metabolic switch that enhances glucose uptake, promotes fat oxidation, and improves insulin sensitivity

Clinical trial data from FDA-approved labeling typically report gastrointestinal adverse effects broadly, with nausea occurring in 1544% of patients depending on the specific agent and dose, while vomiting affects 524% of users