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[4] [ | ] TMLD

While GLP-1 medications like Ozempic, Wegovy, and Zepbound are effective for weight loss, rapid fat reduction can sometimes lead to changes in body appearance that some patients find undesirable

Every enrolled patient already had vascular disease. Whether semaglutide reduces first cardiovascular events in lower-risk people with overweight or obesity is not what SELECT tested, and pretending otherwise overstates what we know. The risk-reduction figures often quoted from the SURMOUNT-5 analysis are based on the Framingham risk equations applied to changes in risk factors they are modelled, not observed. Useful as a hypothesis

Medication alone is rarely sufficient for long-term success