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At the same time, important questions remain, particularly regarding long-term use in larger and more diverse patient populations

Gutzwiller JP, Tschopp S, Bock A, Zehnder CE, Huber AR, Kreyenbuehl M, Gutmann H, Drewe J, Henzen C, Goeke B

Because copper can be toxic at high systemic levels, a reasonable question is whether GHK-Cu poses a copper-overload risk

Results Beta-cell secretion and insulin sensitivity show improvement at 8 weeks Metabolic imbalance challenges redox balance and impairs insulin sensitivity as well as insulin secretion, and glucose control ameliorates these conditions as measured through the homeostatic model assessment index, HOMA (see Figures S12 and S13