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These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma
raised AU$50 million (US$33.15 million) in a private placement of equity securities to advance lead candidate paxalisib, a brain-penetrant dual PI3K/mTOR inhibitor in clinical trials for brain cancer and advanced breast cancer
Compounded at FDA-regulated pharmacies
Li et al., 2011)
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