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June 2026 PharmaTimes Magazine 28-29 // GLP-1 // New balancing Beyond GLP-1 the next wave of obesity drugs and the rise of retatrutide The landscape of weight loss management is rapidly shifting beyond the initial dominance of Ozempic and Wegovy, leading to the emergence of next-generation treatments
On the contrary, a recent clinical trial conducted on humans (male) found that taking 10mg of melanotan 2 before bedtime for three months reduced insulin sensitivity by 12%[5]
Hormones such as ghrelin (which stimulates appetite), leptin (which signals fullness), insulin , and GLP-1 (glucagon-like peptide-1) play major roles in this regulation
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