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The most durable regulatory change has been at the FDA level: the agency has strengthened its enforcement of Orange Book listing requirements, leading to the voluntary delisting of patents that some companies had listed without adequate legal basis
Glucagon receptor activation increases energy expenditure and raises hepatic glucose output
There's no scientific proof of why it happens, but researchers think it could be from bacteria in the urine or a change in how the amino acid tryptophan is being broken down in the body
There are now several clinical trials of GLP-1 therapy for substance use disorders, including alcohol use disorder, underway
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