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dose escalation may be delayed by 1 additional week if necessary: Week 1: Inject 0.6 mg subcutaneously once a day Week 2: Inject 1.2 mg subcutaneously once a day Week 3: Inject 1.8 mg subcutaneously once a day Week 4: Inject 2.4 mg subcutaneously once a day Week 5: Inject 3 mg subcutaneously once a day Maintenance dose : 3 mg subcutaneously once a day-If maintenance dose is not tolerated, discontinuation is recommended

Vitamin B 12 deficiency that results from pernicious anemia can easily be corrected with high-dose daily supplementation or with monthly intramuscular injections of the vitamin (see the article on Vitamin B 12 )

Of note is that GSTP1 also attenuated caspase 3 activity induced by the positive control tamoxifen by 50% (Supplementary Figure S4)

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