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see ESM Methods), or based on glucose-lowering medication use self-reported during annual follow-up calls (semi-annual calls after 2012 through 2020)
Systematic reviews and comparative analyses suggest the following pattern: Dualagonists such as tirzepatide typically produce more weight loss than GLP1 singleagonists
Open 6 , e2255496 (2023)
If you have been on the combination for 8 or more weeks without measurable weight loss improvement beyond what tirzepatide alone was producing, the phentermine is adding risk without benefit and should be discontinued
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