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Beauty and nutrition have become inextricably linked: We keep hearing "beauty from the inside out," in reference to dietary impact on physical appearance and health
My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it
151,152 Additionally, GLP-1 RAs lower oxidative stress within the brain, suggesting neuroprotective benefits that could improve neural health and hinder age-related deterioration
Evidence suggests it may promote weight loss by increasing calorie expenditure.6 Taking an L-Carnitine supplement daily has been proven to increase the blood and muscular concentrations of this amino acid-like compound, which could enhance fat metabolism as a result with increased muscle carnitine concentrations.6 2
