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Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects
Roy said
The most common variant is UGT1A1*28 (rs8175347), a promoter polymorphism where the normal (TA)6 repeat in the TATA box is expanded to (TA)7
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