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There are a couple culprits that people commonly avoid due to specific irritation: - glutathione (some people get a rash and should avoid if they do!) - niacinamide (although soothing for most, it can really aggravate some individuals) - butylene glycol (a common ingredient that many people have to avoid)
J Neurosci Methods
The severe pain in my knees and hands remained unresolved until I tried Pryxo
