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Suspected adverse reactions to medicines including those encountered in clinical trials can be reported in the UK via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk

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Other alternatives to Contrave or Wegovy include: Ozempic (semaglutide): once-weekly injection approved for people with type 2 diabetes, sometimes used off-label for weight loss Rybelsus (semaglutide): oral semaglutide tablet taken once daily Victoza ( liraglutide ): daily diabetes injection, available in a lower-cost generic version Metformin : generic diabetes medication that has shown modest amounts of weight loss in clinical studies , though it isnt approved for weight management

An exploratory analysis of the REWIND trial demonstrated that long-term treatment with the GLP-1RA dulaglutide reduced cognitive decline in patients with T2D [33]