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21 :110-112 Key words: diabetes, cardiovascular outcome trial, semaglutide Licensing requirements for new antidiabetic drugs changed in the USA following the rosiglitazone controversy, and between 2008 and 2020 a dedicated randomised controlled cardiovascular outcome trial (CVOT) was usually required either before or after licensing
Safety reviews have been reassuring across the board
The research described in this article has been published on a preprint server but has not yet been peer-reviewed by scientific or medical experts
The mediators secreted by mast cells trigger the expression of adhesion molecules in the endothelium of vessels responsible for leukocyte migration to the inflammation site (31)
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