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[1] [2] While there is no evidence that weight loss injections directly cause kidney problems in individuals with normal baseline renal function, the SmPCs for both Wegovy and Saxenda do list acute kidney injury (AKI) and renal impairment among reported adverse reactions

Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

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(2000) Peptides n=24 Preclinical studies elucidating ipamorelin mechanism as GH secretagogue distinct from ghrelin receptor agonism