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GLP-1 receptor agonists are a class of medications that mimic a natural hormone in the body, which helps regulate blood sugar, slows digestion, and signals feelings of fullness to the brain

Most participants only received an osteoporosis diagnosis and initiated treatment at the time of fracture, reinforcing the need for early screening strategies

Drug development studies have utilized Angptl4 to determine whether small molecule LPL activators can enhance LPL activity and reverse Angptl4-mediated inhibition (78) were modified prior to docking so that they more closely represented the structures used in the experiments (i.e., LPL without the signal peptide, the region of ApoC-II covered by the synthetic peptide only, and the N-terminal fragment of Angptl4, respectively)