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Although currently FDA-approved for diabetes and weight management, clinical evidence indicates these medications also interact with the brains neurological reward pathways involved in substance use disorder

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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

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