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These studies, which followed thousands of patients over several years, did not demonstrate an increased incidence of fractures compared to placebo or other diabetes treatments
[See Dosage and Administration (2.2).] Hepatic Insufficiency In patients with moderate hepatic insufficiency (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100 mg dose of Januvia
If using the injection, you should take it at least 45 minutes before sexual activity and do not exceed more than one dose within 24 hours
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