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Once the copper is released from the GHK complex inside skin cells, it is used locally by copper-dependent enzymes like superoxide dismutase and lysyl oxidase
This disrupts activation of the ZAKMAPKJNK apoptotic cascade and weakens GCN2-mediated global translation suppression, thereby abolishing p53-independent apoptosis and contributing to chemoresistance against DNA-damaging agents
Agricultural Res
Fribley, A., Zeng, Q
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