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at the University of Arizona established it as a superagonist at melanocortin receptors with substantially greater potency than native -MSH in melanocyte stimulation assays, and confirmed the cyclic lactam structural feature as the key determinant of its enhanced receptor affinity and metabolic stability

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It should be noted that the bell-shaped responses observed in these doseresponse studies were similar to those observed in the Met phosphorylation and dimerization studies (Fig

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