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Under physiological conditions, GLP- 1 is rapidly degraded by dipeptidyl peptidase-4 (DPP- 4) after it is released (7)
The medication was generally well tolerated, with a side effect profile consistent with other GLP-1 receptor agonists.
19-24 Liraglutide has been studied as monotherapy and in combination with metformin, the SU glimepiride, the TZD rosiglitazone, or insulin glargine, and in combination with glimepiride and rosiglitazone, or metformin and an SU
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