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Similarly, a recent study among Turkish nurses found no significant differences in oxidative stress parameters (TOS, TAS, cortisol, epinephrine, and norepinephrine) between day and NS workers, although higher perceived stress and anxiety sensitivity were associated with increased TOS and cortisol levels, suggesting that psychological stress may contribute to oxidative imbalance even in the absence of direct shift-related biochemical changes 83

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Future studies should focus on developing miRNA-based diagnostic assays for early ferroptosis-associated T2D alterations, clinical trials targeting ferroptosis pathways discussing therapeutic interventions, exploring ferroptosiss role in diabetic complications, and understanding the complex web of miRNA-dependent ferroptosis mechanisms for T2D diagnosis and therapy

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