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A multi-branched gatekeeping testing procedure was used to account for multiple comparisons among the primary and key secondary end points in PIONEER 1 to 4, and 8 and a simple hierarchical testing procedure was used in PIONEER 5 and 6, both of which were appropriate methods of control for multiplicity

Clinical studies have demonstrated that patients using Rybelsus achieve substantial reductions in their HbA1c levels compared to those on placebo or other diabetes treatments

Real-world results vary (diet, activity, meds like GLP-1/tirzepatide, sleep, stress)