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We review: Medical history Current medications Weight loss challenges Metabolic and hormonal factors This step determines whether retatrutide is appropriate or if another option may be safer or more effective

Two approaches were used to assess a potential association between semaglutide and NAION: (1) an active-comparator cohort design (assessing outcomes of the new semaglutide users to the other drugs) and (2) a self-controlled case series (comparing risk during exposure vs