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Semaglutide is approved as Ozempic for T2D and CKD in people with T2D, as Wegovy for obesity and reducing the risk of serious heart problems in adults with CVD and either obesity or overweight, and as Rybelsus as an oral medication for T2D
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Adipose tissue aromatizes testosterone to estrogen and contributes to systemic inflammation and insulin resistance, all of which can disrupt the hypothalamicpituitarygonadal (HPG) axis and spermatogenesis
Machado-Vieira R, Salvadore G, Luckenbaugh DA, Manji HK, Zarate JCA
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