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The weight loss factor: If you lost a significant amount of weight (say, 50+ pounds), your body needs time to adjust to its new normal
However, more severe side effects, such as pancreatitis and kidney problems, can occur
The table says dehydration risk is amplified by GLP-1-induced nausea and reduced intake for people on thiazides or loop diuretics, and it lists monitoring electrolytes and fluid status as the clinical consideration, with a diuretic adjustment if needed
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