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Structurally it is built on a modified GIP backbone with non-coded residues (aminoisobutyric acid, -methylleucine) and a fatty-acid conjugate on a central lysine, which together extend its plasma half-life and reduce proteolytic degradation in laboratory assay systems
ICH Q2(R2) states that analytical procedures should be evaluated for characteristics such as specificity, selectivity, range, accuracy, precision, and robustness where applicable [13]
Subjects were stratified by gender to achieve balance of baseline characteristics
Support was also received via Japan Agency for Medical Research and Development (AMED) Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) Grant Number JP18dm0207001 (TCS) and a research grant from the RIKEN Center for Brain Science
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