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3.2 GLP-1R agonists in the central nervous system GLP-1R, expressed in endothelial cells, microglia, astrocytes, and neurons, is widely distributed in the hypothalamus, cortex, subventricular zone, and substantia nigra (Hamilton and Holscher, 2009
Several small observational studies have documented improvements in IBS-related symptoms among patients using semaglutide, including reduced bloating, decreased constipation episodes, and lower abdominal pain scores
Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC--dependent neurocircuitry
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