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They inform biological hypotheses but do not establish clinical efficacy in humans

Some of the most common symptoms include: Abdominal discomfort or pain Recurring diarrhea Blood or pus in the stool Reduced appetite Weight loss Fever Frequency and urgency of bowel movements In more severe cases, patients can develop anemia, cardiac complications and may require blood transfusions

Data indicated that EGCG or Zn alone had limited effects on mitigating weight loss and rectal shortening, whereas EGCG-Zn suppositories significantly alleviated radiation-induced weight loss and restored rectal length ( Fig

It should be noted that GCLM KO mice have systemic GSH deficiencies, ranging from 10 to 40% of normal levels depending on the tissue type 16