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The SUSTAIN studies confirmed that, in addition to their effect on glycemic and weight control in patients with type 2 diabetes, GLP1RAs have the potential to reduce the incidence of major adverse cardiovascular outcomes in high-risk populations

Among these, Glp1r-expressing neurons in the hindbrain, particularly in the dorsal vagal complex composed of AP and NTS, have been identified as critical mediators of GLP1RA effects, providing key insights into the neural circuits underlying obesity therapeutics 15

Colln, A

Although GLP-1 RA are generally associated with greater weight reduction than SGLT2i, which could potentially influence PsA risk, this explanation remains speculative