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Subcutaneous injection provides optimal bioavailability for systemic effects, while topical application targets localized skin concerns
This medication is highly teratogenic (can cause birth defects) and requires participation in the MHRA Pregnancy Prevention Programme for women of childbearing potential, along with regular monitoring of blood tests
The fatty acid tail problem The C18 octadecanedioic acid moiety that gives retatrutide its extended half-life through albumin binding also makes the molecule more lipophilic than unmodified peptides
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